Compass - Comorbidity of Major Depressive Disorder and Autism Spectrum Disorders

Compass - Comorbidity of Major Depressive Disorder and Autism Spectrum Disorders - Compass

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43350

Enrollment

192

Registered

2016-07-21

Start date

2016-09-19

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ASD Autism

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria patients: - ASD diagnosis based on the current Dutch guidelines - MDD diagnosis based on DSM-IV criteria using the Structured Clinical Interview for DSM Disorders I (SCID-I). - Age 18-65 - IQ>70;Inclusion criteria healthy controls: - Age 18-65 - No history of psychiatric disorders

Exclusion criteria

Exclusion criteria: Exclusion criteria patients: - Sensorimotor handicaps - Impaired vision or color blindness - Inadequate command of the Dutch language - Mentally incompetent to sign informed consent;Exclusion criteria all: - Exclusion criteria specifically for the MRI section: o Metal objects in the body (excluding dental fillings) o Jewelry or piercings than cannot be removed o Brain surgery o Epilepsy o Claustrophobia o Pregnancy o Ferromagnetic implants or pacemakers o Inability to lie still for one hour

Design outcomes

Primary

Measure	Time frame
The main objective of this project is to increase knowledge about the specific and shared mechanisms of ASD and MDD on a behavioral, cognitive and neurobiological level.	—

Secondary

Measure	Time frame
The secondary objectives are divided for each domain that will be examined. Neuropsychology Our first aim is to study the nature of the alterations in executive functioning and emotional information processing across stress-related (MDD) and neurodevelopmental disorders (ASD) and in co-morbid ASD with MDD in order to better understand the underlying mechanisms of shared symptoms, like for example impaired emotion regulation, rigidity, rumination or alexithymia. A better recognition of these underlying mechanisms may help to tailor our future treatments to individual patients. Our second aim is to understand the relationship between these cognitive mechanisms and prognosis of patients in sense of general functioning and level of participation. A third aim is to examine neural markers as underlying mechanisms of alterations in executive functioning, emotional information processing and shared symptoms. Neuroimaging We will examine brain activity using functional magnetic resonance imaging (fMRI). In the current protocol a reward- and punishment-based reversal learning task (Cools, Altamirano & D*Esposito, 2006) will be done. In this task the participants have to learn new rules using feed-back with changing contingencies (reward and punishment). As the rules change, the participants have to mentally switch between goals and change their response, therefore it is possible to examine cognitive flexibility. Furthermore, since participants have to learn new rules from both positive and negative feedback, it is possible to examine an affective processing bias. On the behavioral level we can measure accuracy and reaction time. Furthermore, we will examine if activity differences correlate with other measures, such as the outcomes of the questionnaires or neuropsychological	—

Measure

Time frame

The secondary objectives are divided for each domain that will be examined. Neuropsychology Our first aim is to study the nature of the alterations in executive functioning and emotional information processing across stress-related (MDD) and neurodevelopmental disorders (ASD) and in co-morbid ASD with MDD in order to better understand the underlying mechanisms of shared symptoms, like for example impaired emotion regulation, rigidity, rumination or alexithymia. A better recognition of these underlying mechanisms may help to tailor our future treatments to individual patients. Our second aim is to understand the relationship between these cognitive mechanisms and prognosis of patients in sense of general functioning and level of participation. A third aim is to examine neural markers as underlying mechanisms of alterations in executive functioning, emotional information processing and shared symptoms. Neuroimaging We will examine brain activity using functional magnetic resonance imaging (fMRI). In the current protocol a reward- and punishment-based reversal learning task (Cools, Altamirano & D*Esposito, 2006) will be done. In this task the participants have to learn new rules using feed-back with changing contingencies (reward and punishment). As the rules change, the participants have to mentally switch between goals and change their response, therefore it is possible to examine cognitive flexibility. Furthermore, since participants have to learn new rules from both positive and negative feedback, it is possible to examine an affective processing bias. On the behavioral level we can measure accuracy and reaction time. Furthermore, we will examine if activity differences correlate with other measures, such as the outcomes of the questionnaires or neuropsychological

—

Countries

Netherlands

Outcome results