infarction ischemic stroke
Conditions
Interventions
Sponsors
Helsinki University Central Hospital
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Ischemic stroke Age 18 - 49 years Hospitalized due to first-ever imaging postive ischemic stroke without cause found after complete and timely minimum diagnostic testing
Exclusion criteria
Exclusion criteria: Baseline mandatory minimum tests not obtained in the first week following stroke onset, including: a. Brain MRI b. Routine blood tests, including complete blood count with differential, CRP, fasting glucose, creatinine, aPTT, INR, total cholesterol, LDL-cholesterol, HDL-cholesterol, HbA1C, and hemoglobin electrophoresis in individuals of African origin Other baseline mandatory minimum tests not obtained within the first two weeks following stroke onset, including: a. Imaging of cervicocephalic arteries by CTA, MRA, or DSA b. Transesophageal (highly recommended) and/or transthoracic echocardiography (N.B. Early screening of venous thrombosis in the lower extremities is highly recommended in patients with established right-to-left shunt) c. 24-hour Holter monitoring (or continuous in-hospital ECG monitoring for at least 24 h) d. Screening for thrombophilia, including anticardiolipin antibodies, lupus anticoagulant, anti-β2- glycoprotein antibodies, factor V mutation (or aPC resistency ruled out), factor II mutation, homocysteine, antithrombin III, protein C, and protein S. It is highly recommended to retest any abnormal finding >12 weeks from the initial testing or >4 weeks after cessation of anticoagulation at any later time point.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Etiology (TOAST) Mortality New vascular events | — |
Secondary
| Measure | Time frame |
|---|---|
| Risk factors Other outcome (hypertension, diabetes) | — |
Countries
Finland, Norway, Portugal, Turkey
Outcome results
None listed