falling sickness
Conditions
Interventions
None listed
Sponsors
Epilepsiecentrum Kempenhaeghe
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Patients and healthy volunteers need to be 18 years or older and should be able to perceive magnetic stimulation, i.e. do not fulfil any of the exclusion criteria as mentioned in section 4.3. * The patients included should be candidate for a video-EEG recording as part of their pre-surgical investigations. * The decision for withdrawal of AEDs is a clinical decision, which is not influenced by the protocol requirements of this study. * The patients included all are selected to have a pre-surgical simultaneous EEG and fMRI investigation.
Exclusion criteria
Exclusion criteria: * Serious head trauma or brain surgery * Large or ferromagnetic metal parts in the head (except for a dental wire) * Implanted cardiac pacemaker or neurostimulator * Pregnancy * Skin diseases at intended electrode sites (EMG, EEG, TMS)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study parameter is that changes in excitability of the brain studied with MEPs evoked by TMS, are reflected in the EEG either as evoked discharges or as increased rsFC. | — |
Secondary
| Measure | Time frame |
|---|---|
| A secondary endpoint is the rejection of the null-hypothesis that the excitability of the brain is not increased in the condition without the use of AEDs compared to the condition that the patient is on the steady-state maintenance doses of AEDs as prescribed. | — |
Countries
Netherlands
Outcome results
None listed