Hormonal changes in aggressive behavior, an idiographic study

Hormonal changes in aggressive behavior, an idiographic study - Hormonal changes in aggressive behaviour

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43328

Enrollment

Registered

2016-05-19

Start date

2016-04-01

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

aggression anti-social personality disorder

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: The following participants will be included to the study: - Participants without any psychiatric disorder. These will be participants who are confronted with aggressive behaviour in their professional daily life, but do not initiate this behaviour (e.g. mental health nurse, policeman). - Psychotic patients, who have florid psychotic symptoms. They have an axis-I diagnosis of schizophrenia, according to the DSM IV criteria (American Psychiatric Association, 2000) as assessed by a psychiatrist. They have no axis-II diagnosis. - Antisocial personality disordered patients; according to the DSM IV criteria (American Psychiatric Association, 2000) as assessed by a psychiatrist. They have no axis-I diagnosis and have a PCL-r score 26.;In this study, only male participants are included, as it is thought that the hormonal fluctuations in the female reproductive cycle might interact with all our hormonal parameters, especially with the oxytocin levels. Apart from that, the majority of patients treated in the Dutch *TBS* clinics is male.

Exclusion criteria

Exclusion criteria: Participants who are not able to fulfil the intensive measurements because of their severe psychiatric symptoms will be excluded. To determine whether a patient is able to participate in the study, the psychiatrist who treats the patient will be consulted.

Design outcomes

Primary

Measure	Time frame
The total experiment per person will last 30 days. Oxytocin and vasopressin will be measured in urine daily (30 time points), and oxytocin, cortisol and testosterone will be measured in saliva three times per day (90 time points). Motor activity and heart rate will be measured continuously during the 30 day period using a small ambulatory device placed around the non-dominant wrist. Participants will be asked to rate their subjective mood and activity three times per day using a daily log (90 time points). In patients, the nurses of the ward will be asked to rate the mood of the patients as well as any incidents that occurred during the last several hours three times per day (90 time point).	—

Measure

Time frame

The total experiment per person will last 30 days. Oxytocin and vasopressin will be measured in urine daily (30 time points), and oxytocin, cortisol and testosterone will be measured in saliva three times per day (90 time points). Motor activity and heart rate will be measured continuously during the 30 day period using a small ambulatory device placed around the non-dominant wrist. Participants will be asked to rate their subjective mood and activity three times per day using a daily log (90 time points). In patients, the nurses of the ward will be asked to rate the mood of the patients as well as any incidents that occurred during the last several hours three times per day (90 time point).

—

Secondary

Measure	Time frame
N.A.	—

Countries

Netherlands

Outcome results