autoimmune hepatitis drug-induced liver injury non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
Conditions
Interventions
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: * Indication for a biopsy for the diagnosis or monitoring of; AIH, DILI, NAFL or NASH * Eligible for liver biopsy * * 18 years old * Provide informed consent
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: * Contraindication for liver biopsy, determined by the clinician. * Current infectious disease. * Clinically relevant cardiovascular, pulmonary, or renal disease. * Medications with possible immune-modulating effects (e.g., steroids). * History of alcohol or drug abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Immunophenotype of intrahepatic and peripheral blood leukocytes. | — |
Secondary
| Measure | Time frame |
|---|---|
| Histology assessment of liver biopsy Serology Clinical Chemistry and Hematology laboratory results Treatment regime Occurrence of (serious) adverse events | — |
Countries
The Netherlands
Outcome results
None listed