The microbiome of Q Fever Fatigue Syndrome (QFS)

The microbiome of Q Fever Fatigue Syndrome (QFS) - Microbiome of QFS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43296

Enrollment

Registered

2016-11-28

Start date

2017-02-21

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Q fever Q fever fatigue syndrom

Interventions

Microbiome

Q fever

Q fever fatigue syndrome

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Healthy controls (n=30) - Female gender - Age between 18 and 59 years old;QFS patients (n=30) - Female gender - Age between 18 and 59 years old - LCI guideline on QFS diagnosis of QFS - Score >=40 on the subscale fatigue of the Checklist Individual Strength (CIS) at time of diagnosis - Severe functional impairment on Sickness Impact Profile-8 (SIP-8), defined as a SIP total score >=700 at time of diagnosis - Fatigue duration for under 10 years;CFS patients (n=30) - Female gender - Age between 18 and 59 years old - CDC diagnosis of CFS - Score >=40 on the subscale fatigue of the Checklist Individual Strength (CIS) at time of diagnosis - Severe functional impairment on Sickness Impact Profile-8 (SIP-8), defined as a SIP total score >=700 at time of diagnosis - Fatigue duration for under 10 years, or recent progression of symptoms

Exclusion criteria

Exclusion criteria: Healthy controls (n=30) - No pregnancy / nursing - No somatic or psychiatric comorbidity - No complaints of fatigue (no complaints on lifestyle questionnaires) - No use of medication in the last month (except oral contraceptives and / or paracetamol - No vaccination during the last month before the study - No substance abuse in the last 3 months before the study - No history of Q fever, tested with serology;QFS patients (n=30) - No pregnancy / nursing - No somatic or psychiatric comorbidity - No use of medication in the last month (except oral contraceptives and / or paracetamol - No vaccination during the last month before the study - No substance abuse in the last 3 months before the study;CFS patients (n=30) - No pregnancy / nursing - No somatic or pshychiatric comorbidity - No use of chronic or acute medication during the last month before the study (except oral contraceptives and / or paracetamol - No vaccination during the last month before the study - No substance abuse in the last 3 months before the study - No history of Q fever, tested with serology

Design outcomes

Primary

Measure	Time frame
The composition of the gut microbiome (classes of colonizing microorganisms) will be compared between patients and healthy individuals.	—

Secondary

Measure	Time frame
The composition of circulating cytokines will be compared between cohorts The composition of circulating metabolites will be compared between cohorts The correlation of the gut microbiome (classes of colonizing microorganisms) with the circulating cytokines and metabolites, and perceived complaints will be compared within each cohort and between cohorts.	—

Countries

The Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)