Feasibility, reliability and relevance of quadriceps muscle endurance measurements in people with COPD

Feasibility, reliability and relevance of quadriceps muscle endurance measurements in people with COPD - Measuring muscle endurance in COPD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43277

Enrollment

Registered

2017-04-04

Start date

2017-10-23

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

airway obstruction COPD

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1) at least 40 years old, 2) Diagnosis of moderate to very-severe COPD based on spirometry according the GOLD classification, 3) able to provide written informed consent, 4) able to follow verbal directions for testing.

Exclusion criteria

Exclusion criteria: 1) diagnosed with cardiovascular, neurological or neuromuscular conditions that could affect ability to perform the tests (e.g. stroke, knee osteoarthritis); 2) currently participating in a pulmonary rehabilitation program or been involved in pulmonary rehabilitation in the past 6 months; 3) experienced a COPD exacerbation in the past 3 months, 4) receiving a daily dose > 10mg of oral Prednisone within the past 3 months.

Design outcomes

Primary

Measure	Time frame
Reliability of the quadriceps isometric, isokinetic and isotonic endurance will be assessed using a two-way random single measures ICC procedure. Munro*s descriptors will be used to describe the degree of reliability: high, ICC = 0.70 to 0.89 and very high, 0.90 to 1.00. The limits of agreement between measures taken on two days will be established using a Bland-Altman plot for all measurements. The proportion of scores within 2 standard deviations of the mean difference between test-retest values will be used to describe agreement. In order to facilitate the clinical interpretation of reliability results, the minimal detectable change (MDC) at 95% confidence level will be calculated. .	—

Measure

Time frame

Reliability of the quadriceps isometric, isokinetic and isotonic endurance will be assessed using a two-way random single measures ICC procedure. Munro*s descriptors will be used to describe the degree of reliability: high, ICC = 0.70 to 0.89 and very high, 0.90 to 1.00. The limits of agreement between measures taken on two days will be established using a Bland-Altman plot for all measurements. The proportion of scores within 2 standard deviations of the mean difference between test-retest values will be used to describe agreement. In order to facilitate the clinical interpretation of reliability results, the minimal detectable change (MDC) at 95% confidence level will be calculated. .

—

Secondary

Measure	Time frame
Bivariate, linear correlations will be evaluated using a Pearson correlation coefficient for quadriceps isometric, isokinetic and isotonic endurance, and SPPB scores. The strength of the relationship will be described using Munro*s descriptive.	—

Countries

Netherlands

Outcome results