Asthma
Conditions
Interventions
asthma
children
exhaled biomarkers
therapy stratification
Sponsors
Academisch Medisch Centrum
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: Asthma diagnosis: established clinician diagnosis of asthma according to GINA guidelines Treatment: patients receiving GINA step 3,4 or 5 treatment Age: *6 -
Exclusion criteria
Exclusion criteria: Established other pulmonary disease Recent IMP study within 5.5 half lives of the study drug to the date of last drug administration. Not being able to perform lung function measurements due to neurologic disease or developmental delay
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in exhaled biomarker profile, between children responding to treatment and children not responding to treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Target biomarker concentrations of different breath fractions of the same patient will be compared and aggregated at a group level. Assessed parameters will include the reproducibility and the breath fraction that carries the highest chemical information content, highest level of target biomarkers and allows the shortest collection time. Taking these various factors into account an optimal sampling strategy will be selected. This strategy will be used to study the secondary and main study aim. | — |
Countries
The Netherlands
Outcome results
None listed