In vivo and non-invasive measurement of cytokine release in a model of acute and local skin inflammation

In vivo and non-invasive measurement of cytokine release in a model of acute and local skin inflammation - Cytokine measurement following acute and local skin inflammation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43271

Enrollment

Registered

2016-04-14

Start date

2016-05-03

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cytokines inflammatory molecules

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age between 18 and 65 years; Must be willing to give a written informed consent; Must have skin type I, II or III (Fitzpatrick scale).

Exclusion criteria

Exclusion criteria: Diagnosis of histamine hypersensitivity; Predisposition to respond allergic (including diagnosis of allergy to silver or to other device-related material); Presence of cardiac pacemakers or other implanted electric devices; Pregnancy or lactation; Atopic predisposition (i.e. history of allergic rhinitis or allergic conjunctivitis, atopic or contact dermatitis, hay fever, asthma); Any (skin) disease, including possible lesions found during screening; Skin type IV, V, VI (Fitzpatrick scale); Use of immunosuppressive drugs (NSAIDs; biologicals; topical or systemic corticosteroids); Use of antihistamines drugs; Use of medication for hypertension with airway constricting activity (e.g. beta blockers); Excessive sun exposure or tanning at the moment of screening.

Design outcomes

Primary

Measure	Time frame
The main study endpoints are the levels of cytokines at baseline and at different time points following local skin inflammation elicited by histamine iontophoresis.	—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results