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Ventilator - induced lung and systemic inflammation in children with healthy lungs: an explorative study

Ventilator - induced lung and systemic inflammation in children with healthy lungs: an explorative study - Ventilation and inflammation

Status
Unknown
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON43254
Enrollment
35
Registered
2016-12-19
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator - induced lung injury

Interventions

None listed

Sponsors

Universitair Medisch Centrum Groningen
Lead Sponsor

Eligibility

Age
2 Years to 11 Years

Inclusion criteria

Inclusion criteria: • Written Informed consent obtained

Exclusion criteria

Exclusion criteria: • Patients with a history of allergic or respiratory diseases • Known chromosomal disorder • Known immunological disorders • Recent episode of mechanical ventilation

Design outcomes

Primary

MeasureTime frame
The primary endpoint is the level and time course of pulmonary inflammatory mediators including G-CSF, GM-CSF, IFN-, IFN-, IL-1, IL-1RA, IL-2, IL-2R, IL-4, IL-5, IL-6, IL7, IL-8, IL-10, IL-12, IL-13, IL-15, IL-17, TNF-alpha—

Secondary

MeasureTime frame
Level and time course of systemic inflammatory mediators (i.e. G-CSF, GM-CSF, IFN-, IFN-, IL-1, IL-1RA, IL-2, IL-2R, IL-4, IL-5, IL-6, IL7, IL-8, IL-10, IL-12, IL-13, IL-15, IL-17, TNF-alpha) Level and time course of pulmonary 1-antitrypsin concentrations Level and time course of pulmonary sRAGE concentrations Level and time course of systemic sRAGE concentrations—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)