Cardiovascular dose-response to supplemental oxygen in healthy volunteers

Cardiovascular dose-response to supplemental oxygen in healthy volunteers - Dose-response to oxygen

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON43247

Enrollment

Registered

2016-07-29

Start date

2016-09-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovasculaire functie Hyperoxia

Interventions

Breathing FIO2s, ranging between .21 and 1.0, through a non invasive ventilation mask to reach arterial oxygen tension of 20, 40, 60 and max kPa (FIO2 = 1)(with a range of 3 kPa at every concentrati

Cardiovascular

Hyperoxia

Microcirculation

Oxygen

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: 18-55 years of age

Exclusion criteria

Exclusion criteria: - Diagnosed lung pathology (which requires medication or impedes exercise) - Diagnosed left-right shunt - Diagnosed cardiovascular disease

Design outcomes

Primary

Measure	Time frame
The main study parameter is the change in perfused vessel density (PVD) of small vessels (	—

Secondary

Measure	Time frame
Hemodynamics, as measured by Nexfin® finger-cuff - Heart Rate - Mean Arterial Pressure - Cardiac Output - Systemic Vascular Resistance Perfusion Index measured by pulse-oximetry Plasma nitrate levels as an approximation of Nitric Oxide availability. Bioelectrical impedance analysis - Reactance - Resistance - Phase angle	—

Countries

The Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)