Cancer cachexia pancreatic cancer
Conditions
Interventions
None listed
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Cachectic patients with pancreatic cancer (n=11) - Age >= 18 - Planned pancreaticoduodenectomy for suspected adenocarcinoma of the pancreas head (histological evidence not necessary) - Weight loss > 5% in the last six months or BMI 2% or sarcopenia (L3-skeletal muscle index of 2% - Treated with pancreatic enzyme replacement therapy;Non-cachectic patients with pancreatic cancer (n=11) - Age >= 18 - Planned pancreaticoduodenectomy for suspected adenocarcinoma of the pancreas head (histological evidence not necessary) - Weight loss = 20 and weight loss =55 cm2/m2 for men or >=39 cm2/m2 for women) and weight loss = 18 -No history of cancer -Weight loss
Exclusion criteria
Exclusion criteria: -Active acute pancreatitis -Chronic pancreatitis -Previous pancreatic surgery -Inflammatory bowel disease (e.g. Crohn*s disease) -Use of systemic steroids in the past four weeks -Use of anti-inflammatory biological (e.g. TNF-a blockers) in the past four weeks -Abdominal surgery in the past four weeks -Insulin dependent diabetes mellitus -Chronic obstructive pulmonary disease GOLD III and IV -Hearth failure -Total parenteral nutrition at day of surgery -Wheelchair bound -Pregnancy -Neoadjuvant chemotherapy or radiotherapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome parameter in this study is tumour and pancreas specific protein synthesis, expressed as fractional synthetic rate (FSR) [%/day]. This parameter is calculated from: • Plasma and tissue free alanine concentration • Plasma enrichment of alanine • Tissue protein bound enrichment of alanine • Alanine enrichment of the tissue free amino acid pool The FSR can be calculated using the following formula: FSR = ((tissue enrichment biopsy - calculated baseline tissue enrichment)/(saliva enrichment*time of study))*100%. Baseline plasma albumin enrichment will be used to calculate baseline tissue enrichment | — |
Secondary
| Measure | Time frame |
|---|---|
| Tissues/protein-specific FSR will be calculated from: o Albumin o Leukocytes o Vastus lateralis muscle o Rectus abdominis muscle o Liver o Gallbladder o Small intestine o Subcutaneous fat o Visceral fat Plasma protein FSR using an unbiased quadrupole time-of-flight mass spectrometry approach. Regional tumour protein incorporation will be assessed using matrix assisted laser desorption/ionisation mass spectrometry imaging. | — |
Countries
Netherlands
Outcome results
None listed