chronic kidney disease Renal failure
Conditions
Interventions
Oral administration of 4 grams sodium butyrate a day for one month.
Intestinal permeability
Kidney disease
Systemic inflammation
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: For the haemodialysis group: - Haemodialysis patients, stable on dialysis for >6 months ;For the post renal transplantation group: - Functional renal allograft, 6-24 months post transplantation;Furthermore: age 40-70, non-smoking, BMI between 20 and 30.
Exclusion criteria
Exclusion criteria: - Diabetics - Antibiotic treatment within the last 3 months - Probiotic use - Chronic diarrhoea or fulfilling the criteria for irritable bowel syndrome - Irritable bowel disorder or other comorbidity that might affect the intestinal flora - Dysphagia - Active infection (CMV, EBV)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters consist of markers of: - Intestinal permeability: quantitative amount of bacterial DNA in blood, d-lactate, IFAP, indoxyl sulfate - Inflammation: CPR, IL-6, macrophage and monocyte activation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Other parameters include: - Serum and faecal butyrate levels - Lipid spectrum - Changes in gut microbiome - Eating habits evaluated by diet lists - Questionairs evaluating meantal performance and quality of life (RAND-36, HADS) and fatigue (Checklist Individuele Spankracht) | — |
Countries
The Netherlands
Outcome results
None listed