Assessment of central airways mechanics using Magnetic Resonance Imaging (MRI) and bronchoscopy: a comparison

Assessment of central airways mechanics using Magnetic Resonance Imaging (MRI) and bronchoscopy: a comparison - Central Airways Mechanics (CAM)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43232

Enrollment

Registered

2016-07-05

Start date

2017-10-16

Completion date

Unknown

Last updated

2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

tracheo malacia

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: Indication for bronchoscopy as decided by the treating pediatric chest physician Aged 8 years or above Ability to perform spirometry and spirometry controlled or technician controlled MRI Informed consent from the parents/ guardians

Exclusion criteria

Exclusion criteria: Any contra indication for MRI In the case any contra indications to administer bronchodilator, this part of the protocol will be omitted

Design outcomes

Primary

Measure	Time frame
The main study parameter is the sensitivity and specificity of MRI as a diagnostic tool for static and dynamic assessment of airway collapsibility in children. We will determine sensitivity, specificity, PPV and NPV of our MRI protocol compared to flexible bronchoscopy to assess airway collapsibility, the current gold standard for airway assessment in pediatric patients.	—

Secondary

Measure	Time frame
Secondary study parameter is the severity scores of airway collapsibility using MRI and bronchoscopy. Concordance between MRI and bronchoscopy airway collapsibility severity scores will be assessed. Airway collapsibility for both MRI and bronchoscopy will be scored both with categorical and continuous variables.	—

Countries

Netherlands

Outcome results