intrauterine growth restriction Intrauterine growth retardation preeclampsia toxemia of pregnancy
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Women having preeclampsia/intrauterine growth restriction in need of a caesarean section. Women having a normal pregnancy in need of a caesarean section
Exclusion criteria
Exclusion criteria: Both/Cases: In case of operative complications in terms of, for example, excessive blood loss the surgeon in charge may decide that there is no time to perform the placental biopsies. Congenital abnormalities in the foetus.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoint is the correlation between pathological score of placental bed from pregnancies complicated by pre-eclampsia or intrauterine growth restriction and cardiovascular health of the mother. Placental bed pathology will be correlated to placental patholgy. De results of the pilot study will also be included in the analysis. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Utilize and further investigate the feasibility of our newly devised scoring system for spiral artery pathology and the myometrium. - Assessments of feasibility, tissue sampling quality and yield for the detection of acute atherosis lesions in the placental bed. - Investigate local maternal-fetal immune interactions involved in spiral artery remodelling (flow cytometry, transciptomic, mRNA, chromatin analysis) | — |
Countries
Netherlands
Outcome results
None listed