The effects of repetitive tDCS on relapse in cocaine addiction: An ecological momentary assessment (EMA) study

The effects of repetitive tDCS on relapse in cocaine addiction: An ecological momentary assessment (EMA) study - Effects of tDCS in cocaine relapse

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON43214

Enrollment

Registered

2016-09-20

Start date

2016-09-01

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Verslaving Drug dependence Substance abuse

Interventions

One group will receive bilateral tDCS (left cathodal/right anodal) over the DLPFC. The stimulation will take place two times daily for 13 minutes with a rest interval of 20 minutes for five consecut

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Aged between 18 and 65 years Meeting the DSM-V criteria for cocaine dependence The ability to speak, read, and write in Dutch at an eight-grade literacy level No severe withdrawal signs or symptoms at baseline

Exclusion criteria

Exclusion criteria: - Indications of severe psychopathology (psychosis, severe mood disorder) as assessed by a physician; - A diagnosis of epilepsy, convulsions or delirium tremens during abstinence of cocaine; - The intake of medications for psychiatric conditions; - Any contraindication for electrical brain stimulation procedures such as electronic implants or metal implants; - Pregnancy or breast-feeding.

Design outcomes

Primary

Measure	Time frame
Relapse probability in cocaine addicted patients as measured by means of EMA after twice daily sessions of bilateral tDCS (left cathodal/right anodal) over the DLPFC for five consecutive days. The primary study outcome is number of relapse days at three months follow-up. In addition, number of relapse days after one week, craving, temptations and cognitive control will be assessed as possible predictors of relapse days at 3 months follow-up. Craving will be measured at the same moments in time as relapse, by means of five single EMA items. Cognitive control will be determined by inhibitory control and risky decision making. Inhibitory control will be measured by performance on NoGo trials in the Go/NoGo task. Mean number of pumps on the BART task will represent risk-taking.	—

Measure

Time frame

Relapse probability in cocaine addicted patients as measured by means of EMA after twice daily sessions of bilateral tDCS (left cathodal/right anodal) over the DLPFC for five consecutive days. The primary study outcome is number of relapse days at three months follow-up. In addition, number of relapse days after one week, craving, temptations and cognitive control will be assessed as possible predictors of relapse days at 3 months follow-up. Craving will be measured at the same moments in time as relapse, by means of five single EMA items. Cognitive control will be determined by inhibitory control and risky decision making. Inhibitory control will be measured by performance on NoGo trials in the Go/NoGo task. Mean number of pumps on the BART task will represent risk-taking.

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Secondary

Measure	Time frame
The following control variables will be assessed: positive- and negative affect, alcohol/ drug use, life satisfaction, amount of drug use in the past month, starting age of using drugs and current age.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)