apathy psychosis
Conditions
Interventions
None listed
Sponsors
Neurowetenschappen, sectie Cognitieve Neuropsychiatrie
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Individuals with an UHR state: At least 18 years of age UHR state according to the CAARMS interview (administered within 6 months before scanning) The two UHR-groups will be matched on age, sex, education, levels of depressive symptoms, medication and handedness Written Informed Consent;Healthy controls: At least 18 years of age Matched to UHR group on age, sex, education, levels of depressive symptoms and handedness Absence or low levels of apathy Written Informed Consent
Exclusion criteria
Exclusion criteria: Individuals with an UHR state: Use of antipsychotics;Healthy controls: High level of apathy (AES>26) Presence of a psychiatric disorder, in present or past (based on the mini-SCAN).;All subjects: Presence of a neurological or substance dependence disorder Visual or hearing problems that cannot be corrected Insufficient knowledge of the Dutch language Inability to undergo cognitive testing;Additional criteria, due to the use of neuroimaging (all subjects): (Suspected) pregnancy (performed by pregnancy test) Claustrophobia The refusal to be informed (by notifying the participant's physician) of structural brain abnormalities that could be detected during the experiment MR incompatible implants in the body (such as ear prostheses or other metal implants) Risk of having metal particles in the eyes Tattoos containing red pigments that form a safety risk Participation in a scientific research study during the past year involving radiation Smoking or other forms of nicotine intake 24 hours prior to the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter will be the binding potential of [11C]-raclopride.. | — |
Secondary
| Measure | Time frame |
|---|---|
| n.a. | — |
Countries
Netherlands
Outcome results
None listed