distractability lack of motivation
Conditions
Interventions
None listed
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy volunteers between 18 and 45 years of age
Exclusion criteria
Exclusion criteria: Neuropsychiatric disorders; history of drug abuse; heart problems; metal objects in or around the body (see section 4.3 in research protocol (C1) for full list of exclusion criteria)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Baseline dopamine synthesis capacity measured with [18F]-DOPA PET; BOLD signal measured with fMRI; behavioural performance on computerized tasks (measuring reward sensitivity, working memory, reversal learning, reinforcement learning, cognitive effort, the influence of affective information on goal-oriented behaviour, and creativity); subjective measurements (e.g. self-report questionnaires, visual analogue scales); psychophysiological recordings (e.g., blood pressure, heart rate, respiration, elctrocardiography); blood and saliva sample to assess dopamine genes for pathway-based genetics analysis. | — |
Secondary
| Measure | Time frame |
|---|---|
| All tasks in the cognitive testing battery (computerized tasks) result in both outcomes of primary interest (see section 7.1.1 in the study protocol) and additional outcomes (see section 7.1.2 in the study protocol). Our secondary objective is to further our understanding of the relationship between baseline dopamine synthesis capacity and baseline measures - such as working memory, genetic differences, impulsivity and eye-blink rate * to assess how baseline levels of dopamine mediate the effects of the drug on the secondary outcomes from the cognitive testing battery. | — |
Countries
Netherlands
Outcome results
None listed