Blood flow to leg muscles measured with phase-contrast MRI during supine exercise in patients with chronic heart failure.

Blood flow to leg muscles measured with phase-contrast MRI during supine exercise in patients with chronic heart failure. - MR-FLOW trial

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43173

Enrollment

Registered

2016-12-12

Start date

2017-05-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic heart failure diminished pump-function of the heart.

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Phase 1: Healthy volunteers in the age of 18-50 years that are able to perform maximal exercise test. Phase 2: Patients with systolic heart failure (dilating or ischemic), NYHA-class II/III and ejection fraction

Exclusion criteria

Exclusion criteria: Phase 1: Cardiovascular disease and Orthopaedic, pulmonary, neuromuscular and other diseases limiting exercise capacity. Claustrophobia. Phase 2: Recent myocardial infarction (

Design outcomes

Primary

Measure	Time frame
Phase 1: Difference and agreement of blood flow (L/min) in the ascending (CO) en distal aorta (LBF) measured with PC-MRI in rest en during submaximal exercise between two days. Phase 2: Difference of DF (ratio) between patients with CHF and healthy, age-matched controls.	—

Secondary

Measure	Time frame
N.A.	—

Countries

Netherlands

Outcome results