Barrett's esophagus
Conditions
Interventions
Patients will be drinking 2 bottles per day of a LcS containing drink (Yakult),
for a period of 4 weeks.
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age > 18 years Histopathological proof of Barrett's esophagus (BE) without dysplasia BE length of >2 cm (C2Mx) Signed informed consent
Exclusion criteria
Exclusion criteria: Probiotic use within the last 3 months before baseline. Antibiotic use within the last 2 months before baseline. Infection in the oral cavity. Esophagitis according to the Los Angeles classification (gr. A-D) Immunocompromised patients; HIV-infection, systemic immunosuppression therapy Patients with diabetes mellitus Previous gastric/esophageal surgery, which has changed esophageal anatomy Other coexistent esophageal disease (e.g. varices) Patients with bleeding disorders Other situations that contraindicate gastroscopy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Amount of LcS bacteria (16S rDNA analysis) 2. Bacterial Gr+/Gr- ratio in the esophagus (both in BE and in squamous epithelium) (16S rDNA analysis of the esophageal flora (with and without LcS)). | — |
Secondary
| Measure | Time frame |
|---|---|
| 3. Amount of pathogenic bacteria i.e. Campylobactor spp, Veilonella spp, Neisserria spp (16S rDNA sequencebased metagenomic analysis). 4. Immunological response to the change in microbiome (Micro-array based analysis of the expression profiles of immune responses gene). 5. Presence of inflammation (endoscopic observation). | — |
Countries
Netherlands
Outcome results
None listed