veroudering ageing increasing age
Conditions
Interventions
None listed
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy young subjects (n
Exclusion criteria
Exclusion criteria: - Contra-indication for DEXA-scan, e.g. metal splinters - Contra-indication for muscle biopsy, e.g. use of anticoagulants. - a significant medical or surgical event or hospitalization within the previous three months - currently or the last three months treated by a medical specialist - diagnosed with cardiac failure, COPD or anaemia - diagnosed dementia and not having access to a daily caregiver and not able to make their own trade-off, which will be assessed at our discretion. The potential subjects have to be able to reproduce what is said; - diagnosed with cancer or receiving cancer treatment - not able to understand the Dutch language - Diagnosed neuromuscular disorders - taking carnitine supplements - current participation in other research - usage of the following medications: o Systemic corticosteroids o Fibrates o Valproic acid o Emetine o Zidovudine;Additional exclusion criteria for the young individuals: - Pregnant and nursing women - Diabetes Mellitus type I and II - Limited amount of performing sports, not more than 5 times a week
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study paramater is intramuscular carnitine levels and the intramuscular carnitine derivatives. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary study parameters are: - carnitine status and its derivates in PBMCs - mitochondrial function in muscle tissue and PBMCs - Fat and fat-free mass - Plasma carnitine and its derivatives - Short Physical Performance Battery - 400m walk time - Cognitive function | — |
Countries
Netherlands
Outcome results
None listed