An exploration of intestinal bacterial biofilms in Lynch syndrome patients as disease markers for colorectal cancer

An exploration of intestinal bacterial biofilms in Lynch syndrome patients as disease markers for colorectal cancer - Bacterial biofilms in colorectal cancer

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43143

Enrollment

140

Registered

2017-01-05

Start date

2017-03-14

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lynch syndroom Colorectal cancer in Lynch syndrome patients

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Lynch patients who are scheduled for multiple colonoscopies. Other patients who are scheduled for multiple colonoscopies. (control)

Exclusion criteria

Exclusion criteria: - antibiotics in the past 3 months. - a history with inflammatory diseases of the intestine. - vaccination to prevent colorectal cancer. - coagulation disorders or patients taking anti-coagulation medicine. - a (sub)total colectomie

Design outcomes

Primary

Measure	Time frame
Revealing an assocation between the presence of biofilms and the development of colorectal cancer in Lynch patients.	—

Secondary

Measure	Time frame
- Determining the effects of biofilms on the mucosal tissue of the colon - Determining the effects of biofilms on oncogenesis markers in epithelial cells - Studying which bacteria are present in the biofilm and determining which bacteria could be potentially pathogenic	—

Countries

Netherlands

Outcome results