gastrointestinal activity intestinal barrier function
Conditions
Interventions
Ingestion of multi-sugar and glutamine- alanine solutions to evaluate
intestinal barrier function in 4 different experimental protocols as described
in study design.
Sponsors
Hogeschool Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Male • Generally healthy • Recreational athlete with at least two years of cycling experience of at least twice a week • 18-35 years old • Meeting criteria of valid max-test • Body mass index (BMI) 20-25 kg/m2 • Veins suitable for blood sampling at inspection
Exclusion criteria
Exclusion criteria: -Known symptoms of immune diseases such as diabetes, celiac disease, gastric disease -Known symptoms of intestinal diseases such as Crohn*s disease, colitis ulcerosa, irritable bowel syndrome fibrosis -Smoking -Use of hard drugs --Chronic use of NSAIDs: aspirin, ibuprofen, etc. -Drugs for gastric and/or intestinal function - Participation in other scientific studies -Blood donation during the last six weeks prior to the start of the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are the relative changes in blood, urine and saliva of markers of intestinal barrier function (iFABP, lactulose/rhamnose ratio, zonulin), immune responsiveness (e.g. leukocytes) and of markers reflecting general physiological changes (e.g. cortisol). These parameters were most clearly affected in the study GRINTA!. As a new parameter we include RNA-profiling of blood cells, as indication of functional alterations in leukocytes. | — |
Secondary
| Measure | Time frame |
|---|---|
| The relative changes in blood, urine and saliva of markers of intestinal barrier function (iFABP, lactulose/rhamnose ratio, zonulin), immune responsiveness (e.g. leukocytes) and markers reflecting general physiological changes (e.g. cortisol) in an intermediate-intense (moderate) exercise. | — |
Countries
Netherlands
Outcome results
None listed