A follow-up of infants born following intrauterine growth restriction: Is there a relation between neonatal cerebral tissue oxygenation and developmental outcome at 4 years?

A follow-up of infants born following intrauterine growth restriction: Is there a relation between neonatal cerebral tissue oxygenation and developmental outcome at 4 years? - DINGfu study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43109

Enrollment

Registered

2016-06-10

Start date

2016-12-13

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ontwikkelingsstornissen fetal growth retardation intrauterine growth restriction (IUGR) ontwikkeling

Interventions

None listed

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: - Survivor of the IUGR cohort of a previous study performed in the UMCG, METc number 2012-055 - Near-infrared spectroscopy (NIRS) data available from the first week after birth - Written informed consent

Exclusion criteria

Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: - Chromosomal disorders - Congenital infections - Significantly impaired hearing or vision - Inability to understand/speak Dutch

Design outcomes

Primary

Measure	Time frame
The total IQ based on the Wechsler Preschool and Primary Score of Intelligence (WPPSI) with subdivision into the verbal IQ and the performance IQ.	—

Secondary

Measure	Time frame
a) The emotional and social behaviour as assessed with the Children Behavior Checklist (CBCL), the executive functioning assessed with the Behavior Rating Inventory of Executive Function-Preschool Version (BRIEF-P), and the developmental progress as assessed by the Ages and Stages Questionnaire (ASQ). b) The DNA methylation using DNA isolated from stool specimens and buccal swabs.	—

Countries

Netherlands

Outcome results