Reversal of opioid-induced respiratory depression (OIRD) by ketamine in healthy volunteers * the ORKA trial

Reversal of opioid-induced respiratory depression (OIRD) by ketamine in healthy volunteers * the ORKA trial - ORKA

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON43104

Enrollment

Registered

2016-08-25

Start date

2016-10-21

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

opioid-geinduceerde ademdepressie Opioid-induced respiratory depression

Interventions

Infusion of ketamine on top of a remifentanil infusion.

ketamine

respiration

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Healthy male and female volunteers, aged 18 and older

Exclusion criteria

Exclusion criteria: - Known or suspected neuromuscular or a (family) history of any neuromuscular disease; - A history of allergic reaction to food or medication including study medication; - Any current or previous medical (including high blood pressure), neurological or psychiatric illness (including a history of anxiety); - Alcohol abuse (> 21 units/week); - Illicit drug use in the past 30 days before inclusion; - Pregnancy or lactation; - Participation in any medical or drug trial in the month prior to the current study.

Design outcomes

Primary

Measure	Time frame
Ventilation	—

Secondary

Measure	Time frame
-	—

Countries

The Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)