aging elderly
Conditions
Interventions
During the experiment participants undergo TMS and peripheral nerve
stimulation, while they are standing in 5 different postures:
Condition 1: Standing with a wide base stance (Stand WB): Standing
aging
balance
transcranial magnetic stimulation (TMS)
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Young group: 18-40 years. Old group: over age 65
Exclusion criteria
Exclusion criteria: 1. Unable to stand independently for 10 minutes without rest 2. Epilepsy 3. Any metal in the brain/skull 4. Electrical, magnetic, or mechanical implantation: cardiac pacemakers or intracerebral vascular clip 5. Pregnancy or suspicion of pregnancy 6. History of seizures or unexplained loss of consciousness 7. Immediate family member with epilepsy 8. Use of seizure threshold lowering medicine 9. History of Schizophrenia 10. History of Hallucinations 11. History of other neurological disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are the size of the short-interval intracortical inhibition (SICI) and Hmax/Mmax ratio. SICI is the inhibition of the test motor evoked potential (MEP), when the suprathreshold TMS pulse (the test stimulus) is preceded by a few milliseconds with a subthreshold TMS pulse (the conditioning stimulus). SICI is a measure of motor cortical inhibition, and can thus be used to examine cortical influences. The Hmax/Mmax ratio, on the contrary, is a measure of the spinal influence. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary study parameters are the Multiscale Entropy (MSE) complexity index of the CoP, and the modulation indices. The modulation indices are the percentage difference in SICI and Hmax/Mmax between normal and supported standing, and between the 5 standing conditions. | — |
Countries
The Netherlands
Outcome results
None listed