The role of perivascular adipose tissue in the regulation of insulin sensitivity through muscle microvascular recruitment in individuals with obesity or type 2 diabetes before and after bariatric surgery.

The role of perivascular adipose tissue in the regulation of insulin sensitivity through muscle microvascular recruitment in individuals with obesity or type 2 diabetes before and after bariatric surgery. - PVAT, metabolism and vascular health.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43075

Enrollment

Registered

2017-01-06

Start date

2017-01-02

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes

Interventions

Capillary recruitment

insulin sensitivity

PVAT

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Female -Caucasian -age 18-55 years -BMI is *35 kg/m2 Bariatric surgery participants getting an operation at the OLVG, location West. Control participants getting a cholecystectomy at the OLVG west.

Exclusion criteria

Exclusion criteria: Documented CVD -Stage 2 hypertension (resting blood pressure >160/100 mmHg) -Obstructive sleeping apnea syndrome (OSAS). -History of severe inflammatory conditions in the past 15 years -Recent infections -recent history ( 4 U/day, more than 3 days in a row -Use of medication potentially affection insulin sensitivity, microvascular function or inflammation -Use of anticoagulants (types Warfarin and Coumadin derivatives) that can increase the risk of bleeding during the muscle biopsy (exception is made for aspirin). -Malignancies (except those of the skin), renal and hepatic diseases. -Smoking -Recent (10%) changes in body weight.

Design outcomes

Primary

Measure	Time frame
From the pre- and post operative time points we will study functional and inflammatory properties of PVAT and correlate them with whole-body and microvascular insulin sensitivity. We will correct for anthropometry and systemic inflammation and circulating adipocytokines (IL-6, IL-8, leptin, TNF-*, MCP-1, adiponectin, resistin and PAI-1, fibrinogen) .	—

Secondary

Measure	Time frame
-	—

Countries

The Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)