zelf-reflectie en open staan voor mening van anderen it involves healthy subjects. This study is not aimed at a certain disorder
Conditions
Interventions
Cognitive insight
Mindfulness
Processing of self-related social feedback
Sponsors
Neurowetenschappen
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: * Being right-handed (based on Edinburgh Handedness inventory questionnaire) * Age 18-65 * Normal (or corrected to normal) vision * fMRI-compatible * Capable of giving informed consent * Fluent in written and spoken Dutch
Exclusion criteria
Exclusion criteria: * Not matching any of the inclusion criteria * Matching any criterion in the fMRI exclusion list, including, but not limited to, claustrophobia, infarctions, epilepsy or family history of epilepsy, presence of metal inside the body, presence of electric/electronic devices inside the body (pacemakers, etc.), presence of intracardial lines, (suspicion of) pregnancy, tattoo(s) that contain red pigment, any risk of having metal particles in the eyes * Non-removable dentures * Use of medication that can influence task performance. For example, medication that target blood pressure or heart rate (e.g. beta-blockers). Also, use of antidepressants, anxiolytic, and anti-epileptic drugs * Use of drugs such as cannabis, XTC or other recreational drugs * Presence or history of neurological, psychiatric or substance dependence disorder * Previous mindfulness or other formal meditation experience
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are brain activation and/or connectivity during tasks, and brain (functional and structural) connectivity during resting state, in relation to cognitive insight. Blood-oxygen-level-dependent (BOLD) signal will be measured during the performance of two different tasks and at rest using fMRI. In addition, a special kind of diffusion-weighted imaging (DWI) called diffusion tensor imaging (DTI) will be used to examine the relationship between the integrity of white matter tracts and cognitive insight, while structural MRI scans will be used to examine grey matter volume in relationship to cognitive insight. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters are cognitive test scores on the Sustained Attention to Response Task (sustained attention, inhibition and meta-awareness). | — |
Countries
The Netherlands
Outcome results
None listed