fysiologie effect of the mismatch between sweetness and calories
Conditions
Interventions
Calories are manipulated with non-sweet polymer maltodextrin content at two
levels: 75 and 150 kcal. Sweetness is manipulated with sucralose at 2 levels:
equivalent to sweetness of a 75 kcal or 150
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Right handed * Age 18 * 35yr * BMI 18.5 - 25 kg/m2 * Being healthy (self-reported) * Having given written informed consent (see E2)
Exclusion criteria
Exclusion criteria: * Not meeting the inclusion criteria * Drug use or medical conditions which may interfere with normal functioning of the digestive tract * Drug use or medical conditions which may interfere with normal functioning of the circulatory system Drug use or medical conditions which may lead to unreliable fMRI results (including, but not limited to neurological conditions) * Food allergy to or unwillingness to consume the study products * Reported unexplained weight loss or weight gain of > 5 kg in the month prior to pre-study screening * Presence of non-removable metal objects in the mouth * Personnel of Wageningen University, department of Human Nutrition * Current participation in other research from the Division of Human Nutrition * Having a contra-indication to MRI scanning * Disliking the food items.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Change in resting energy expenditure in kcal/day 2. Change in gastric emptying rate in mm3/min 3. Change in cerebral blood flow in mL/100*g·min | — |
Countries
Netherlands
Outcome results
None listed