intestinal permeability nutrient absorption
Conditions
Interventions
Intake of 100grams of peanuts and a dual sugar solution (5gr lactulose and 1 gr
rhamnose), whether or not followed by a cycling test (1 hour 75% Wmax)
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - 20-35 year old male or female - Body mass index (BMI) 23-27.5 kg/m2 - Suitable veins for blood sampling - No inhibitory matrix effect in Ara h6 ELISA method - Able to cycle 1h on ergometer
Exclusion criteria
Exclusion criteria: - History of peanut allergy - Known symptoms of immune disease, such as diabetes, gastritis, and coeliac disease. - Pregnant or lactating - Known symptoms of intestinal disease, such as Crohn*s Disease, ulcerative colitis, and irritable bowel syndrome. - Smoking - Use of hard drugs - Use of specific medicines: o Chronic use of NSAIDs: aspirins, ibuprofen, etc. o Drugs having an effect on gastric and/or intestinal function and motility, including antidepressants. - Participation in other scientific studies - Blood donation during the last six weeks before the start and during the study - Employed at Human Nutrition, Human and Animal Physiology, or Consumer Science and Health(FBR) or performing an internship/thesis at any of these places.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is the serum Ara h6 level after intake of peanuts with and without exercise | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome is the lactulose/rhamnose ratio in plasma after intake of the dual sugar solution with and without exercise | — |
Countries
Netherlands
Outcome results
None listed