lungaeration Newborns
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: o Gestational age 25 * 42 weeks o Written informed consent from both parents or legal representatives
Exclusion criteria
Exclusion criteria: o Postmenstrual age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Study parameters/endpoints Main study parameter/endpoint 1. The change in lung aeration in the first 60 minutes after birth assessed by: a. End-expiratory lung volume (*EELV) b. Absolute tidal volume c. Tidal volume distribution 2. The regional distribution of these changes in EELV and tidal volume distribution assessed by: a. Left to right lung ratio b. Dependent to non-dependent lung ratio c. Geometric Center of Ventilation (CoV) d. Silent spaces or percentage atelectasis | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Assess possible differences between the timing of lung aeration between term and preterm infants based on short and long time constants (*) 2. Assess possible differences between the timing of lung aeration between infants born via the vaginal route and those born via caesarian section 3. Assess the association between changes in lung aeration and the vital parameters heart rate and oxygen saturation measured with pulse oximetry (SpO2). In a subgroup of patients, we will also assess the association between lung aeration and airway pressure and volume (see study procedure). | — |
Countries
Netherlands
Outcome results
None listed