Mitochondrial disorders
Conditions
Interventions
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: Healthy children: o Healthy children aged 4-16 years old;Children with a mitochondrial disorder: o Genetic mutation leading to a mitochondrial disorder o Being capable of following instructions
Exclusion criteria
Exclusion criteria: Healthy children: o Having a known health condition that could affect the physical activity, such as Attention Deficit Hyperactivity Disorder (ADHD), for which he/she visited the general practitioner or a paediatrician. o Visited the general practitioner or a paediatrician for tiredness in the past year;Children with a mitochondrial disorder: o The study is estimated to be too burdensome to the patient o Daily use of a wheelchair
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Study i) The feasibility of the accelerometers during the movement-protocol in lab-gym situation, and the validity of the different parameters calculated by the software of the accelerometers compared to visual observations (video). Study ii) The validity, feasibility and test-retest reliability of the selected accelerometer in measuring habitual physical activity of children with a mitochondrial disorder during a longer period in the home situation | — |
Secondary
| Measure | Time frame |
|---|---|
| The different parameters calculated by the software of the selected accelerometer, i.e.: o Activity counts (counts/minute) o Physical activity intensity (% sedentary, % light, % moderate, % vigorous) o Steps taken (n) o Body position (% laying, % sitting, % standing, % walking) o Energy expenditure (MET-rates, kcal) o Sleep-parameters (total sleep time, sleep efficiency, sleep onset latency and wake after sleep onset) | — |
Countries
The Netherlands
Outcome results
None listed