Celiac disease
Conditions
Interventions
During a 12 week period, both groups will take capsules on 6 time points
containing either gluten (3 times) or placebo (rice-starch) (3 times) with a 2
week washout period
Sponsors
Rijnstate Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients with biopsy proven coeliac disease, Marsh IIIA or higher at time of diagnosis, adhering to a gluten-free diet and aged 18 years or older are eligible if: - They report clear symptoms on gluten exposure - They report excellent or no problems with dietary adherence (score 13 or less) on the Celiac Disease Adherence Test (CDAT)(8) (Appendix 2) - They report scores resembling clinical remission (score 30 or less) on the Celiac Symptom Index (CSI)(9) (Appendix 3) - Serum TTG and EMA levels are non-detectable during gluten-free diet - Negative GIP in urine/ faeces at the start of this study
Exclusion criteria
Exclusion criteria: Patients will be excluded if; - They report other CDAT and/or CSI scores - They are pregnant - They have known gastroenterological co-morbidity - They have malignant disease - They use painkillers or other drugs to reduce symptoms
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The correlation between the presence of GIP in urine/ faeces and symptoms after gluten provocation | — |
Secondary
| Measure | Time frame |
|---|---|
| None | — |
Countries
Netherlands
Outcome results
None listed