MRKH syndrome caused by Intrauterine Placental Transfusion between sex-discordant twins?

MRKH syndrome caused by Intrauterine Placental Transfusion between sex-discordant twins? - MIPT study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43018

Enrollment

Registered

2016-12-28

Start date

2017-03-02

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mayer - Rokitansky - Kuster - Hauser (MRKH) syndrome

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients: - Diagnosed with MRKH syndrome - 18 - 50 years;Control group: (already sampled as control patients in a previous study) - 18 - 50 jaar

Exclusion criteria

Exclusion criteria: - not willing or able to sign the informed consent - reported pregnancy (in the control group)

Design outcomes

Primary

Measure	Time frame
The presence of chimerism in MRKH patients, determined by Y-chromosome-specific real-time quantitative polymerase chain reaction.	—

Secondary

Measure	Time frame
In addition we want to test if the chimerism is only confined to blood, by testing (micro)chimerism in non-hematopoietic tissue (buccal smear) in MRKH patients. If the chimerism is present in the blood, but not in this non-hematopoietic tissue, this supports the idea that the chimerism is a result of blood sharing via intrauterine placental connections.	—

Countries

Netherlands

Outcome results