kanker neuroendocrine tumor
Conditions
Interventions
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for all subjects: - written informed consent - age above 18 years Inclusion criteria for patients with a NET: (one of these) - histologically proven NET, with or without treatment for the NET - a diagnosis made by a dedicated NET specialist based on a combination of physical symptoms and signs, imaging and laboratory values. Inclusion criteria for healthy subjects: - Matching in age (plus or minus 3 years) and sex with one of the included NET patients. Data of healthy subjects could also be used from the SERT-study, if the subject meets the criteria mentioned above.
Exclusion criteria
Exclusion criteria: Exclusion criteria for all subjects: - Use of drugs or food supplements that interact with the serotonin-metabolism; all serotonin re-uptake inhibitors, psychotrophic drugs, (other antidepressants; tricyclic antidepressants, MAO-inhibitors, mirtazapin, bupropion, venlafaxin, duloxetin, anxiolytic, antipsychotic and anticonvulsive drugs). - Drug abuse in the last 8 weeks. - Use of >= 14 alcoholic consumptions a week for women. - Use of >= 21 alcoholic consumptions a week for men. Exclusion criteria for healthy subjects: - Having a neuroendocrine tumor or neuroendocrine carcinoma from any grade and location in present or in history. - Having a malignancy. - Having an auto-immune disease. - Having an infection. - Having renal impairment. - Use of interferon.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In this exploratory study we will measure the indol profile in patients with a foregut NET, mid- and hindgut NET, and healthy volunteers at the time of diagnosis and during follow up and treatment in plasma and urine. | — |
Secondary
| Measure | Time frame |
|---|---|
| In addition, levels of catecholamines and metabolites in these three groups will be determined. | — |
Countries
The Netherlands
Outcome results
None listed