hersenaandoeningen cerebrovascular disease
Conditions
Interventions
None listed
Sponsors
Geriatrie
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Young adult group: aged 18-30 years * Elderly group: aged *65 years * Normal cognition, determined by MoCA Score * 26 * Able to provide informed consent
Exclusion criteria
Exclusion criteria: * Diagnosis of significant neurological or psychiatric diseases relevant for brain function or (cerebral) blood flow (e.g. stroke, dementias) * History of brain surgery * Diabetes mellitus, cardiovascular disease, hypertension, epilepsy * Carotid artery stent or severe stenosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebrovascular perfusion is examined at the level of the middle cerebral artery using TransCrandial Doppler (TCD, in cm/s) and cerebral cortex using near infrared spectroscopy (NIRS; concentration oxy/deoxy Hb in mmol/L). Furthermore, common carotid artery blood flow is measured with ultrasound (cm/s). These measurements will be performed before and across a 3-minute period of the CPT. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secundary parameters are ECG (3 lead), blood pressure (Finapres), and end-tidal CO2. | — |
Countries
Netherlands
Outcome results
None listed