Cardiac ischemia due to physical or mental stress in women with suspected coronary microvascular dysfunction (CMD)

Cardiac ischemia due to physical or mental stress in women with suspected coronary microvascular dysfunction (CMD) - Cardiac ischemia in CMD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42965

Enrollment

Registered

2016-07-26

Start date

2017-03-01

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary microvascular dysfunction Coronary microvascular dysfunction (microvascular angina pectoris)

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Women 40-65 years, with a clinical diagnosis of CMD; based on symptoms and/or signs of ischemia, the presence of multiple CV risk factors and absence of obstructive coronary artery disease - CMD with symptoms of ischemia at least twice a week

Exclusion criteria

Exclusion criteria: - Symptoms of ischemia due to obstructive CAD - An altered diurnal rhythm, such as by working night shifts or insomnia.

Design outcomes

Primary

Measure	Time frame
Occurrence of cardiac ischemia (defined as >= 1.5 mm ST segment depression in >=3 consecutive cardiac cycles) in the 24 hours following a mental or physical stress test.	—

Secondary

Measure	Time frame
- Relation between stress test and cortisol and hs CRP levels - Time between stress test and occurrence of ischemia	—

Countries

Netherlands

Outcome results