bacteraemia Sepsis
Conditions
Interventions
None listed
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • >18 years • Following infections: o Positive blood culture pathogenic Gram positive bacteria (eg. Staphylococcus aureus (at least 10 with S. aureus), Streptococci) o Positive blood culture with a pathogenic Gram negative bacteria (eg. E. coli (at least 10 with E. coli), K. pneumoniae) • Expected duration of in-patient care of at least 3 days. • Signed informed consent
Exclusion criteria
Exclusion criteria: • Use of platelet function inhibitors (except aspirin) • Antibiotic therapy for longer than 72 hours • Myocardial infarction or stroke in the previous year • An active hematologic or solid malignancy • Terminal renal failure requiring dialysis • Insulin dependent diabetes mellitus • Solid organ transplant requiring anti-inflammatory medication • Use of anti-inflammatory agents such as prednison (>7.5mg) or use of targeted biological agents (eg. TNF-blockers, monoclonal antibodies) with the exception of NSAIDs • Micro-organisms that are well known contaminants in a blood culture (e.g. coagulase negative staphylococcus)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Platelet transcriptome during and after bacteraemia. 2) Platelet function and platelet-leukocyte interaction | — |
Secondary
| Measure | Time frame |
|---|---|
| 3) Platelet granule content (proteomics) 4) microparticle levels and phenotype during disease. | — |
Countries
Netherlands
Outcome results
None listed