Hookworm Necator americanus
Conditions
Interventions
Four volunteers will be exposed to 50 Necator americanus L3 larvae. Volunteers
will be followed on a weekly basis until week 12 after infection. If volunteers
develop a patent infection, defined by
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. 1. Subject is aged * 18 and * 45 years. 2. Subject has adequate understanding of the procedures of the study and agrees to abide strictly thereby. 3. Subject is able to communicate well with the investigator, is available to attend all study visits. 4. Subjects are able to respond to phone or email within 24 hours during the first 12 weeks of the study. 5. Subject agrees to refrain from blood donation to Sanquin or for other purposes throughout the study period. 6. For female subjects: subject agrees to use adequate contraception and not to breastfeed for the duration of study. 7. Subject has signed informed consent.
Exclusion criteria
Exclusion criteria: 1. 1. Any history, or evidence at screening, of clinically significant symptoms, physical signs or abnormal laboratory values suggestive of systemic conditions, such as cardiovascular, pulmonary, renal, hepatic, neurological, dermatological, endocrine, malignant, haematological, infectious, immune-deficient, psychiatric and other disorders, which could compromise the health of the volunteer during the study or interfere with the interpretation of the study results. These include, but are not limited to, any of the following: * History of severe asthma or other health conditions that may require future steroid use; * body weight 30.0 kg/m2 at screening; * positive HIV, HBV or HCV screening tests; * the use of immune modifying drugs within three months prior to study onset (inhaled and topical corticosteroids and oral anti-histamines exempted) or expected use of such during the study period; * Having one of the following laboratory abnormalities: ferritine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detection of hookworm eggs by faeces microscopy (Kato-Katz) at any week between week 9 to 12 post-infection. | — |
Secondary
| Measure | Time frame |
|---|---|
| None | — |
Countries
Netherlands
Outcome results
None listed