MRI Accelerated Cognitive Ageing in Epilepsy study (MACA-E)

MRI Accelerated Cognitive Ageing in Epilepsy study (MACA-E) - MACA-E

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42924

Enrollment

Registered

2016-11-25

Start date

2017-02-06

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

neurologische problematiek, nl epilepsie epileptic seizures neurological disease with seizures

Interventions

ageing

cognition

epilepsy

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Patient groups: -age 18 to 80 -cryptogenic or symptomatic epilepsy -premorbid FSIQ > 70;Healthy controls -age 18-80 -premorbid FSIQ > 70

Exclusion criteria

Exclusion criteria: - mental retardation (FSIQ

Design outcomes

Primary

Measure	Time frame
The main study parameters are: 1. Cognitive parameters, i.e. the neuropsychological parameters for global cognitive decline ( * 1SD discrepancy between current IQ and estimated premorbid IQ [4]), information processing speed, attention and memory. 2. MRI parameters: macrostructural, microstructural and functional, and blood brain perfusion.	—

Secondary

Measure	Time frame
Secondary study parameters are: 1. Demographic parameters: gender, handedness, level of education. 2. Epilepsy related factors: type of epilepsy (i.e. cryptogenic, symptomatic), age at onset, seizure duration, seizure frequency per year, seizure type, history of SE. 3. Clinical factors: medical history, type and dose of medication.	—

Countries

The Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)