chronic kidney disease chronic renal insufficiency
Conditions
Interventions
All participants will undergo a urinary acidification test with ammonium
chloride.
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients with CKD: - Male or female adults (*18 years) - Chronic kidney disease stage 4 (eGFR: 15-30 ml/min/1.73 m2) Healthy subjects: - Healthy male or female adults (* 18 years) - Normal kidney function (eGFR > 90 ml/min/1.73 m2)
Exclusion criteria
Exclusion criteria: Patients with CKD: - Plasma bicarbonate level 5.5 mmol/l - Sodium bicarbonate use in the month preceding the study - Heart failure (NYHA III or IV) - Liver cirrhosis (Child Pugh B or C) - Blood pressure >140/90 mmHg despite the use of 3 different anti-hypertensives - Kidney transplantation - Use of calcineurin inhibitors - Known urea cycle disorder - Alcoholism or drug use - Pregnancy - Current use of antibiotics, NSAIDS or alkalizing drugs (sodium-bicarbonate, citric acid, potassium citrate, acetazolamide) - Inability to adhere to the study protocol (due to language barrier or intellectual disability);Healthy subjects: - eGFR
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study parameter is the change in urinary renin values (an accepted measure of intrarenal RAS activity). | — |
Countries
Netherlands
Outcome results
None listed