Het betreft hier een pilot studie voor gezonde proefpersonen, uiteindelijk zal deze techniek op het gebied van bloedvataandoeningen worden toegepast stenotic vessels vessel calcicifation
Conditions
Interventions
aortoiliac
blood flow
contrast agents
high frame rate ultrasound
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: healthy, slim (BMI below 22), willingness to undergo MRI scan, willingness to undergo echoPIV examination
Exclusion criteria
Exclusion criteria: * Hypersensitivity to the active substance(s) or any of the excipients in SonoVue * Right-to-left cardiac shunt * Severe pulmonary hypertension (pulmonary artery pressure > 90mmHg) * Uncontrolled systemic hypertension * Pregnancy * Lactation * Participation in another clinical trial within 3 months prior to the experimental day * The standard MRI exclusion criteria (pacemakers, cerebral vascular clips, pregnancy, claustrophobia)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the feasibility of high framerate CEUS in deep arterial structures, in this case the distal aorta, to obtain blood flow velocities over the longitudinal section of the vessel lumen. If feasibility is proven a patient study will be planned, including patients treated for AIOD. | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation of high speed CEUS with MRI phase contrast data to validate the obtained results Determine near wall accuracy of obtained velocities. Determine needed amount of contrast to obtain good quality data | — |
Countries
The Netherlands
Outcome results
None listed