Q-fever Fatigue Syndrome (QFS) - a relation with upper respiratory tract infections?

Q-fever Fatigue Syndrome (QFS) - a relation with upper respiratory tract infections? - QFS - Upper respiratory tract infections

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42875

Enrollment

Registered

2017-04-04

Start date

2017-05-30

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronische vermoeidheid Chronic Fatigue Q fever Fatigue Syndrome

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: QFS patients (n = 10 - 15) - Meet the LCI guideline on QFS criteria for QFS - Age >= 18 - Self report of frequent upper respiratory tract infections on outpatient clinic (>= 3 upper respiratory tract infections a year).;Healthy individuals (n = 10-15) - Age >= 18

Exclusion criteria

Exclusion criteria: QFS patients (n = 10 - 15) - No use of immune suppressive medication in the past 3 months;Healthy individuals (n = 10-15) - No past Q-fever infection (serology) - No chronic Q-fever - No Q-fever vaccination - No use of immune suppressive medication in the past 3 months

Design outcomes

Primary

Measure	Time frame
1. Cytokine concentrations of monocytes ( from healthy blood donors) that were trained with C. burnetii and re-stimulated with several viral particles, and of monocytes, from QFS patients, that were stimulated with several viral particles. 2. Histone modifications surrounding the promoter regions of set cytokines, after training with C. burnetii in healthy blood donors and in QFS patients.	—

Secondary

Measure	Time frame
3. Outcomes of SIP and CIS questionnaires on limitations and fatigue, related to cytokine concentrations and histone modifications. 4. Clinical description of complaints / symptoms of QFS patients.	—

Countries

Netherlands

Outcome results