osteoarthritis damaged knee and knee replacement
Conditions
Interventions
To receive daily either Peptan® or placebo (maltodextrin) supplement for 12
weeks.
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Planned for total knee replacement therapy • > 18 years old and mentally competent
Exclusion criteria
Exclusion criteria: • Current use (latest use one week or less before inclusion) of anti-inflammatory supplements (like glucosamine, chondroitin, green-lipped mussel, curcumin or blackcurrant leaf). • Diagnosed with Rheumatoid Arthritis • Medical history of renal insufficiency • Daily use of high doses NSAIDs in the 14 days before inclusion: Defined as higher than maintenance dose (in the "farmacotherapeutisch kompas") for example: acetylsalicylic acid > 4 g /day; diclofenac > 75 mg/day; naproxen > 500 mg/day; ibuprofen> 1600 mg /day; celecoxib >200 mg/day Use of systemic corticosteroids • Vegetarians • Childbearing potential • Inability to perform the functional tests due to other impairments than the knee that is to be replaced
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective is to investigate the effect of collagen peptides (Peptan®) on pain and knee function in patients undergoing total knee replacement therapy. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary objectives are to assess the effect of collagen peptides (Peptan®) on the amount and period of pain reducing therapies, synovial inflammation, wound healing, muscle and knee function, mobiliteit clinical outcome parameters (e.g. PROMS) in patients undergoing total knee arthroplasty | — |
Countries
Netherlands
Outcome results
None listed