The impact of dopamine on functional and structural connectivity

The impact of dopamine on functional and structural connectivity - Dopamine and neural connectivity

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42846

Enrollment

160

Registered

2016-08-25

Start date

2016-09-01

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

wetenschappelijk onderzoek met gezonde vrijwilligers healthy

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy right-handed subjects, who have no personal relationship with the researchers. Female subjects will be taking hormonal contraceptive medication to limit fluctuations in dopamine function associated with the menstruation cycle

Exclusion criteria

Exclusion criteria: Significant history of head trauma, learning disabilities, neurological or psychiatric illness, use of anti-depressants or psychotropic medication, and possible pregnancy (in adult females). Smoking, to avoid nicotine withdrawal effects during the study. MRI contra-indications, including metal implants and claustrophobia. Alcohol consumption

Design outcomes

Primary

Measure	Time frame
~MRI data acquisition~ Following the approved protocol P13.282 Norepinephrine and neural processing, functional neuroimaging will be performed at the 3T fMRI scanner of the LIBC, located in the the LUMC. One resting state fMRI scan series for functional connectivity lasts approximately 8 minutes, whereas a series for structural connectivity lasts approximately 10 minutes. For registration purposes, one T1-weighted scan will be acquired for each subject. ~DNA samples~ Following the approved protocol FC02 Fludrocortisone and depression-related cognition, genetic profile will be determined by collecting mucus with buccal swabs, i.e. swabbing the inside of one*s cheek. Buccal swabs will only be used for the purposes described and will be stored at FSW at -20 °C after completion of the session until biochemical analysis takes place. ~Statistical analysis~ Results of each subject will be compared based on genotype, using analysis of variance. This approach permits detecting differences in resting-state brain activity and structural connectivity between individuals of different genotypes.	—

Measure

Time frame

~MRI data acquisition~ Following the approved protocol P13.282 *Norepinephrine and neural processing*, functional neuroimaging will be performed at the 3T fMRI scanner of the LIBC, located in the the LUMC. One resting state fMRI scan series for functional connectivity lasts approximately 8 minutes, whereas a series for structural connectivity lasts approximately 10 minutes. For registration purposes, one T1-weighted scan will be acquired for each subject. ~DNA samples~ Following the approved protocol FC02 *Fludrocortisone and depression-related cognition*, genetic profile will be determined by collecting mucus with buccal swabs, i.e. swabbing the inside of one*s cheek. Buccal swabs will only be used for the purposes described and will be stored at FSW at -20 °C after completion of the session until biochemical analysis takes place. ~Statistical analysis~ Results of each subject will be compared based on genotype, using analysis of variance. This approach permits detecting differences in resting-state brain activity and structural connectivity between individuals of different genotypes.

—

Secondary

Measure	Time frame
n.v.t.	—

Countries

Netherlands

Outcome results