microvascular dysfunction NSTEMI
Conditions
Interventions
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Stable angina (CCS class I to III, or Braunwald class I) or NSTE-ACS (Chest pain within the preceding 5 days and an index event >24 hours from time of angiography but within the previous 7 days).;2. Scheduled for percutaneous coronary intervention or intracoronary evaluation of functional stenosis severity (diagnostic catheterization).;3. The presence of at least one normal or minimally diseased reference coronary artery (
Exclusion criteria
Exclusion criteria: 1. Younger than 19 or older than 80 years of age.;2. Recent ST-segment elevation myocardial infarction (13 mm).;7. Extremely tortuous or calcified coronary arteries precluding intracoronary physiologic measurements.;8. Women of child bearing age not on active birth control;9. Inability to sign an informed consent, due to any mental condition that renders the subject unable to understand the nature, scope, and possible consequences of the trial or due to mental retardation or language barrier.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To document the magnitude of microvascular resistance in patients with NSTE-ACS versus patients with stable coronary artery disease, as obtained from Doppler flow velocity-derived and thermodilution mean transit time-derived surrogates of coronary flow. | — |
Secondary
| Measure | Time frame |
|---|---|
| To document the relative magnitude of absolute coronary flow and coronary flow reserve in patients with NSTE-ACS versus patients with stable coronary artery disease, as obtained from Doppler flow velocity-derived and thermodilution mean transit time-derived surrogates of coronary flow. To determine the relationship between Doppler flow velocity-derived and thermodilution-derived mean transit time-derived surrogates of coronary flow, coronary flow reserve, and the derived indices of microvascular resistance. To determine the effect of intravenous versus intracoronary administration of adenosine on maximal coronary flow and coronary flow reserve. To determine the relevance of correction of coronary flow and coronary flow reserve for the loss of perfusion pressure after intravenous administration of adenosine. To determine the potential of advanced analysis of the coronary angiogram for the assessment of coronary flow and resistance parameters through fluid dynamic modelling. | — |
Countries
The Netherlands
Outcome results
None listed