Altered interferon-gamma response in patients with Q-fever fatigue syndrome

Altered interferon-gamma response in patients with Q-fever fatigue syndrome - QFS - IFNgamma

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42843

Enrollment

104

Registered

2016-07-25

Start date

2016-05-03

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Q-fever Q-fever fatigue syndrome

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • Diagnosis of QFS according to national LCI-guideline Q fever fatigue syndrome (QFS); • Score >=40 on the subscale fatigue of the Checklist Individual Strength (CIS) at time of diagnosis • Severe functional impairment on Sickness Impact Profile-8 (SIP-8), defined as a SIP total score >=700 at time of diagnosis; • Age >=18.

Exclusion criteria

Exclusion criteria: • Use of immunosuppressant drugs in the past 3 months ; • Pregnancy; • Use of doxycycline in the past 6 months.

Design outcomes

Primary

Measure	Time frame
• Cytokine concentrations (IL-2 and IFNγ) • CIS score, subscale on fatigue	—

Secondary

Measure	Time frame
- Chemokine levels of CXCL 8/9/10/11 - Q-fever serology , using Immunofluorescence Assay (IFA)	—

Countries

Netherlands

Outcome results