CLE and OCT in diagnosing ILD, a comparison with imaging and pathology.

CLE and OCT in diagnosing ILD, a comparison with imaging and pathology. - Optical biopsy for diagnosing ILD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42794

Enrollment

Registered

2015-09-16

Start date

2015-10-19

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ILD Interstitial lung disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - *18 years of age - Supected ILD and referred for diagnostic bronchoscopic procedure with cryobiopsy

Exclusion criteria

Exclusion criteria: - Smoked in the last 6 months - Inability and willingness to provide informed consent - Inability to comply with the study protocol

Design outcomes

Primary

Measure	Time frame
- To describe and develop visual descriptive image criteria for pCLE images of the alveolar compartment in ILD - To describe and develop visual descriptive image criteria for pCLE images of airway wall mucosa in ILD - To obtain quantitative measures of the alveolar compartment in ILD by pCLE imaging (cellularity, fluorescence, size of opening alveolar duct (µm)) - To develop descriptive image criteria and a classification of pOCT images of the alveolar compartment in ILD - To obtain quantitative measures of the alveolar compartment in ILD by pOCT imaging (size of alveolar duct openings, fiber thickness)	—

Measure

Time frame

- To describe and develop visual descriptive image criteria for pCLE images of the alveolar compartment in ILD - To describe and develop visual descriptive image criteria for pCLE images of airway wall mucosa in ILD - To obtain quantitative measures of the alveolar compartment in ILD by pCLE imaging (cellularity, fluorescence, size of opening alveolar duct (µm)) - To develop descriptive image criteria and a classification of pOCT images of the alveolar compartment in ILD - To obtain quantitative measures of the alveolar compartment in ILD by pOCT imaging (size of alveolar duct openings, fiber thickness)

—

Secondary

Measure	Time frame
- Assessing procedure-related adverse events of pCLE and pOCT - Assessing technical feasibility of pCLE and pOCT - To develop an CLE and OCT image atlas for sarcoidosis in mucosa and the alveolar compartment - To conduct exploratory breathprints from ILD patients by electronic nose, for the purpose of building a breathcloud	—

Countries

Netherlands

Outcome results