effect van stress op connectiviteit in het brein stress-related psychiatric disorders
Conditions
Interventions
All participants will be subjected to either the stress or control condition of
the Trier Social Stress Test, a validated and standardized test to induce a
psychosocial challenge in laboratory setti
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age between 18 and 50 years old Diagnosed with bipolar I disorder (patient group only)
Exclusion criteria
Exclusion criteria: General exclusion criteria for all subjects: - Any previous neurosurgery or neurological disorder, including epilepsy - History of head injury resulting in unconsciousness lasting at least 1 hour - Mental retardation - Any contraindications MRI - Subjects who do not fully comprehend the purpose or are not competent to make a rational decision whether or not to participate - Lack of fluency in the Dutch language - Speech impairments - Self-reported current or past drug use in the last week - Positive urine screen on the presence of amphetamines (including MDMA), cannabinoids, cocaine and opiates) - Current neurological or endocrine disorder including alcohol or drug abuse or dependence - claustrophobia - Any acute illness - Physical exertion within the last 2 hours - Use of medication which might influence the stress response, such as beta blockers and any hormonal treatment (including steroids).;Additional exclusion criteria for healthy controls: - Current Axis-I psychiatric disorder - First-degree relative with a current Axis-I psychiatric disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effects of mental challenge on functional connectivity in the brain during rest and during emotion and reward processing. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Change in levels of cortisol, alpha-amylase, heart rate and perceived stress levels - (epi)genetic variation in a number of genes involved in stress | — |
Countries
Netherlands
Outcome results
None listed