Het onderzoek wordt bij gezonde personen uitgevoerd. Het onderzoek kan voor nieuwe inzichten zorgen bij therapeutische interventies voor pijn en jeuk. not applicable
Conditions
Interventions
In the oxytocin with suggestions and oxytocin without suggestions groups,
participants will receive a 24 IU dose of oxytocin via a nasal spray. In the
placebo groups, participants will receive a pla
Sponsors
Universiteit Leiden
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Female between 18 and 35 years old - Good understanding of written and spoken Dutch
Exclusion criteria
Exclusion criteria: - Refusal to give written informed consent - Pregnancy or breast feeding - Conditions that might interfere with the participant's safety and/or the study protocol: severe somatic or psychological morbidity (e.g., heart and lung diseases, or DSM-IV psychiatric disorders, Raynaud*s phenomenon) - Chronic or acute itch or pain complaints - Current use of analgesics, anti-inflammatory drugs, antihistamines, antibiotics
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are self-reported pain in response to the Cold Pressor Test and self-reported itch in response to the histamine iontophoresis. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary parameters are skin temperature, flare response, and wheal size in response to the histamine iontophoresis, unpleasantness ratings in response to the Cold Pressor Task. Furthermore, the possible influence of psychological parameters on outcomes will be explored as well. | — |
Countries
Netherlands
Outcome results
None listed